Young is healthy, but he was sent home after Detroit's loss to the Green Bay Packers Nov. 18 for conduct detrimental to the team. He missed last week's game against the Houston Texans and was allowed to return to practice this week, but the team decided not to activate him.
Young has 24 receptions for 383 yards and four touchdowns this season. Ryan Broyles has played more in his absence.
The Colts' inactives list includes: wide receiver Nathan Palmer, safety Tom Zbikowski, running back Robert Hughes, tight end Dominique Jones, offensive lineman Bradley Sowell and Tony Hills and defensive lineman Kellen Heard. Joe Lefeged will get the start for Zbikowski.