At its surface, it's a lopsided affair between a Niners team with a chance at a first-round bye on the line against a team with nothing to lose in Arizona. If recent history is any indicator, then the 49ers' Week 8 24-3 rout over the Cardinals could be a microcosm of what can happen when the 49ers have their turn to play host.
But what do the experts think?
The experts at Yahoo! Sports have the 49ers taking care of business at home. Every member of their panel selected San Francisco. The same goes for USA Today. Accuscore supports each of those sites and says that the Niners have an 87 percent chance of emerging victorious.
Given the stakes, talent disparity and strong support from experts, it appears that the 49ers will have no issues ending their season on a high note.