In each of the last five games between the Rams and Bills, the over has been the winning bet.
The Bills earned a convincing 34-18 victory against the Jaguars at home in sloppy conditions, dominating on the ground as Fred Jackson and C.J. Spiller pounded out a combined 186 yards rushing. The Rams also picked up a victory with an overtime win against the 49ers in which the St. Louis defense was able to hold Colin Kaepernick and company to 13 points.
The two franchises have faced each other 10 times all-time, but Sunday's game will be the first since 2008. The Bills earned a 31-14 victory in that game and won the meeting before that in 2004, 37-17.
With an over/under set at 42, Sunday's game in Buffalo is expected to be one of the more low scoring affairs of Week 14.