St. Louis is in search of its first winning streak of the season after consecutive victories over the Arizona Cardinals and the San Francisco 49ers. The Rams have managed a 5-6-1 record with many solid defensive efforts. In those two wins, the Rams held the Cardinals to 17 points and returned two interceptions for touchdowns, then kept the 49ers to just 13 points.
The Bills have won two of their last three to move to 5-7 on the year. In their Week 13 win over the Jacksonville Jaguars, running backs Fred Jackson and C.J. Spiller combined to rush for 186 yards. Buffalo averages 347 yards of offense per game behind the league's fourth-best run game.
At CBS Sports, the experts have pegged the Rams to pick up the victory, where five of the eight pickers chose St. Louis. The two experts at Yahoo! Sports who have posted picks have also chosen the Rams, while a majority of Yahoo! users are siding with the Bills.