As expected, the 49ers will be without the services of wide receiver Mario Manningham this week against the Dolphins. Manningham has quickly become one of Colin Kaepernick's favorite targets, but a shoulder injury has him sidelined this week.
Due to the injury, 49ers' first-round pick A.J. Jenkins is expected to make his debut for San Francisco today, as well as second-round pick LaMichael James, who will be active today while Brandon Jacobs is inactive.
For the Dolphins, which are already hobbled after they lost tackle Jake Long to a triceps injury last week, they must take on the challenge of stopping the 49ers without safety Jimmy Wilson, one of their most important contributors on the back end.