Freeney suffered an ankle injury in the Colts' season opener against the Chicago Bears and has not practiced all week. Third-year linebacker Jerry Hughes will fill in for Freeney. Hughes recorded 15 tackles for Indianapolis in 2011.
Here's Vikings coach Leslie Frazier on how not having Freeney would impact game planning:
"Well, Dwight is one of those game wreckers now," Frazier said this week. "He has been for a long, long time. I witnessed him just destroying offenses' game plans and people just changing their game plans because of Dwight, much like they do here with Jared (Allen).
"So, to not have Dwight on the field, it would definitely change how offenses approach you. It would change how we would approach the Colts if he didn't play. That's just the way it is. He's that dominant of a player, even at this stage of his career. He's still a guy that can change the game."
For more on the Colts, head over to the SB Nation blog Stampede Blue.