After winning their season opener, the Patriots surprisingly find themselves 1-2. New England is coming off a very hard-fought defeat at the hands of the Baltimore Ravens and could be in a dangerous position with a third straight loss.
Buffalo, on the other hand, is feeling good, coming into the affair with a two-game winning streak. The Bills also get Fred Jackson back after missing two games; however, C.J. Spiller will be out with a shoulder injury.
Over at ESPN.com, the three experts (and Accuscore) that have made picks all side with Bill Belichick's team to rebound on the road.
The men at CBSsports.com have also made their selections, favoring the Patriots by a 4-to-3 margin both against the spread and straight up. Despite the Bills being the home team, many seem to feel New England is due and desperate not to fall two games under .500.