On a positive note for Cleveland, running back Trent Richardson will play, despite having a bit of a banged-up knee. He is expected to see a full workload.
In addition to Massaquoi, running back Brandon Jackson, quarterback Thaddeus Lewis, offensive tackle Ryan Miller and tight end Alex Smith are the offensive players that will sit out. Jackson is out for the third consecutive game. The defense isn't as heavily hamstrung, as safety Eric Hagg and linebacker James-Michael Johnson are the only two defenders on the list. Johnson was a limited participant in practice during the week as he continues to deal with an oblique injury.
No big names will be out for the Ravens, who will sit offensive tackle Jah Reid, wide receiver LaQuan Williams, cornerback Asa Jackson, tight end Billy Bajema, defensive end DeAngelo Tyson, linebacker Sergio Kindle and defensive tackle Bryan Hall.
Kickoff between the Browns and Ravens is scheduled for 8:20 p.m. ET from M&T Bank Stadium in Baltimore, Md.