Nicks missed last week's game with a foot injury, and earlier in the week it looked like he would be ready to come back. But according to Dan Hanzus of NFL.com, the wideout has now developed swelling in his knee.
In Week 2, Nicks caught 10 passes for 199 yards and a touchdown against the Tampa Bay Buccaneers.
Since being drafted out of North Carolina in 2009, Nicks has been one of Eli Manning's favorite targets. In his career, the receiver has averaged 74.3 yards per game.