NFL odds and lines 2013, Week 6: Cardinals vs. 49ers

Cary Edmondson-USA TODAY Sports

The 49ers are double-digit favorites over the Cardinals after a convincing win on Sunday Night Football.

The San Francisco 49ers are huge favorites over the Arizona Cardinals in Week 6. According to Oddsshark, the 49ers are currently favored by 12.5 points, with the over/under set at 41.

The Vegas line opened at -7.5 in San Francisco's favor, but quickly moved into double digits after the 49ers destroyed the Houston Texans, 34-3. They easily covered the four-point line in that game. After a rocky start to the season, the 49ers won two in a row and are back in the thick of the NFC West race. They are 3-2 against the spread this season.

The Cardinals played a sloppy, turnover-filled game in Week 5, but they ended up making fewer mistakes and beat the Carolina Panthers, 22-6. They entered the game as three-point underdogs and were able to cover by winning. Arizona has yet to be favored this season, but with a 3-2 record, that has worked out well for bold gamblers so far. The Cardinals are now 4-1 against the spread.

For more betting details on this matchup, check out Oddsshark.

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