Rarely does an injury to a non-quarterback affect a team like Calvin Johnson's has with the Lions. One of the premier offenses in the league looked lost in its nine-point effort in Green Bay last Sunday. The news this week isn't encouraging, as Megatron will once again be a game-time decision for Detroit with a sore hamstring.
Another top wideout, Larry Fitzgerald, will have his status decided Sunday when Arizona plays the division-rival 49ers. He and quarterback Carson Palmer have connected for just one touchdown in five weeks, as the Cardinals continue to lack production in the passing game.
After Nick Foles was all but declared the starter for the Eagles earlier this week, Michael Vick's hamstring injury has progressed to the point where he is in the mix to play this weekend. The 2-3 Eagles will be playing the tumultuous Bucs with a chance to keep pace in the depressingly sordid NFC East.
Here are the game-by-game injury reports after Friday's practices:
Chiefs vs. Raiders
Kansas City will be thin at tight end on Sunday, with Anthony Fasano doubtful and backup Travis Kelce a no-go in practice Friday. Like the Chiefs' tight end woes, the Raiders are crippled at the running back position. Darren McFadden and Rashad Jennings are both listed as questionable with hamstring injuries, though versatile back Marcel Reece seems good to go with his knee injury. The Raiders will also be missing S Tyvon Branch and C Stefen Wisniewski when they try to unseat the 5-0 Kansas City Chiefs.
For the Packers, they will enter Sunday without the services of Clay Matthews. Their stud linebacker has a broken thumb and will be out "multiple weeks," according to the Milwaukee Journal-Sentinel. Green Bay's defense will be further hamstrung by -- wait for it -- hamstring injuries that will keep CB Casey Hayward and LB Brad Jones out of the lineup against Baltimore. Running back James Starks has also been ruled out for Sunday with an injured knee, but starter Eddie Lacy doesn't appear on the injury report after returning to game action last week. On the Ravens side, the interior of the defensive line is banged up. Terrence Cody is doubtful with a knee injury that has kept him out of practice all week. Next to him on the D-line is Haloti Ngata, who also didn't practice Friday due to a hip injury. Ngata is questionable to play Sunday.
The Bengals enter Sunday with a fairly clean bill of health, with CB Leon Hall and LB Michael Boley the only contributors questionable to play against Buffalo. Both players were limited in practice Friday due to hamstring injuries. The Bills, however, have injury issues at marquee positions, including quarterback. Rookie E.J. Manuel is out, and practice squad call-up Thad Lewis is in for play-calling duties. Feature back C.J. Spiller and top wideout Steve Johnson remain question marks to play this week with respective ankle and back injuries.
Matthew Stafford is quickly running out of targets in the passing game. Calvin Johnson is a threat to miss his second straight game with a bum knee, and WR Nate Burleson and TE Tony Scheffler have both been ruled out for Sunday. For Cleveland, LB Quentin Groves is questionable after an ankle injury limited his participation in practice Friday.
For the Rams, the ground attack could be in jeopardy as RB Zac Stacy and T Rodger Saffold are both questionable after being limited in practice Friday. Stacy is fighting a rib injury, and Saffold is still hampered by the knee he injured on Sept. 15 against Atlanta. On the Texans side, standout WR Andre Johnson is a game-time decision after being limited in practice with a nagging shin injury.
Carolina's health on defense continues to be a problem, and CB D.J. Moore is set to miss his third straight game with a knee injury. Compounding the issue are injuries to DT Dwan Edwards and S Robert Lester, who are doubtful with hamstring injuries. The big news for the Vikings is the death of Adrian Peterson's son. The All-Pro running back has stated he will not miss Sunday's game, but this bears watching. As for injuries, Vikings kicker Blair Walsh is dealing with a hamstring tweak that has him questionable for this week's game.
The Jets took big hits on each side of the ball this week, with WR Santonio Holmes CB Dee Milliner declared out for Sunday's game. Holmes has a foot injury, and rookie Milliner is dealing with a hamstring. Pittsburgh is at full-strength this week, as QB Ben Roethlisberger and TE Heath Miller are both expected to play.
Eagles vs. Buccaneers
Michael Vick, originally ruled out of Sunday's game, has now been thrown into the mix to start at quarterback for the Eagles. After fully practicing Friday, Vick is officially listed as questionable. For the Bucs, two offensive starters are question marks after being limited in Friday's practice. Guard Carl Nicks is dealing with an injured foot, and WR Mike Williams has a hamstring issue. Both are listed as questionable.
The Jaguars' historically stagnant offense will be without three players on Sunday: QB Blaine Gabbert, TE Marcedes Lewis and WR Stephen Burton. Chad Henne will start under center for Jacksonville for the third time this season while Gabbert sits with a strained hamstring suffered last Sunday against the Rams. While Broncos fans should celebrate the debut of CB Champ Bailey, their defense may be taking a "one step forward, two steps back" approach to health. DE Robert Ayers and LB Wesley Woodyard are both doubtful, which could make it difficult for Denver to cover a 26-point spread.
For the Titans, key offensive cogs Jake Locker and Shonn Greene remain out. Ryan Fitzpatrick and a stifled Chris Johnson will try to keep pace with a dangerous Seattle team. On the defensive side five players have been declared questionable, including DT Sammie Lee Hill and DE Derrick Morgan. On the Seahawks side, Marshawn Lynch popped up on the report as questionable, though no injury was listed. TE Zach Miller is questionable, and LB Bobby Wagner is doubtful with an ankle injury.
For New Orleans, WR Lance Moore and RB Mark Ingram are listed as questionable, though Ingram did practice in a limited capacity. Sitting with a knee injury will be S Roman Harper, who hasn't played since Sept. 15. On the Patriots side of things, WR Danny Amendola and RB Stevan Ridley are questionable. The season-long question mark -- TE Rob Gronkowski -- has been declared out, as has defensive tackle Tommy Kelly. With injuries peppering their roster on both sides of the ball, the 4-1 Patriots could be the least-threatening division leader in the NFL.
For Arizona, Larry Fitzgerald remains the only question mark entering Sunday. The Pro Bowl wide receiver is dealing with a different hamstring injury than the one that bothered him earlier in the season, according to Kent Somers of the Arizona Republic. One of the better units in the NFL over the last few seasons, the 49ers' defense has some questions this week. Among players listed as questionable are LB Patrick Willis, CB Carlos Rogers, DT Justin Smith, DT Ray McDonald and CB Nnamdi Asomugha. Only McDonald didn't participate in practice Friday, with the other four seeing limited action.
For the Redskins, starting running back Alfred Morris was a go in practice Friday. His ribs appear to be game-ready, and he is listed as probable on the injury report. Dallas, however, will be without running back and return man Lance Dunbar. The backup missed practice Friday with a hamstring injury.
For all the injury news for week, head over to NFL.com