According to Oddsshark.com, the Broncos are favored by seven points against Indianapolis with an over/under of 55.5.
Denver comes in with nothing short of an offensive juggernaut led by Mr. Manning. The former Colts legend has been almost perfect this year, throwing 22 touchdowns and only two interceptions. On the flip side, the Broncos have the worst pass defense in the NFL, giving up more than 330 yards per game through the air.
Indianapolis is trying to rebound from a tough and surprising loss on Monday night against the San Diego Chargers on the road. The Colts at 4-2 are leading the AFC South by one game over the Tennessee Titans and two games over the Houston Texans.