Headed into this contest, the host Browns are -4.5 favorites with an over/under of 41, according to Oddsshark.com.
In the Browns case, no team has been on such a roller-coaster of emotion this season. After coming into the campaign with pretty high expectations nationally, the Browns immediately looked awful and lost their first two games.
After first-year general manager Mike Lombardi traded away former No. 3 overall pick Trent Richardson to the Indianapolis Colts, everybody declared Cleveland dead. Not so fast. With Brian Hoyer replacing Brandon Weeden behind center, the Browns have ripped off two straight wins and find themselves tied for the AFC North lead.
On the other hand, Buffalo is 2-2 after dispatching the Baltimore Ravens 23-20 at home on Sunday. The Bills picked off Joe Flacco five times, including two interceptions courtesy of rookie linebacker Kiko Alonso.