Before the season, this AFC South matchup was considered one of the biggest games on the schedule, but the teams have gone in opposite directions. The Texans limped to a 2-5 start and have all but given up on the season, starting Case Keenum over Matt Schaub. Once again, their defense collapsed after losing Brian Cushing. Meanwhile, the Colts put the NFL world on notice with defining wins over the Seahawks, 49ers and Broncos. How they deal with the loss of Reggie Wayne will be a storyline to follow.
Nearly every expert online is picking the Colts. Ten out of 13 ESPN analysts predict the Colts to win, and six of nine people at CBS Sports are favoring Indianapolis. At Yahoo Sports, both NFL writers picked the Colts, as is the user poll.