McFadden, who also is working through a knee injury, was just hurt in the first half of last week's game against the Eagles and has missed time earlier in the season with a similar injury.
The veteran back is averaging just 3.6 yards per carry this season and the Raiders will likely turn to Rashad Jennings to shoulder much of the load, who picked more than 100 yards rushing and 74 yards receiving last week against Philadelphia.
On the other side, running back Brandon Jacobs is once against out for the New York Giants. Jacobs, who rejoined the team in mid-September after a number of injuries at the position, put up 106 yards on 22 carries against the Bears on Oct. 10 and has not played since. The Giants possess the NFL's worst rushing attack and despite having missed nearly a month of action, Jacobs remains the team's leading rusher with just 154 yards total on the season.
Kickoff is set for 1 p.m. ET.