NFL odds and lines, Week 13: Rams vs. 49ers

The odds are in the home team's favor in the Week 13 matchup between NFC West foes.

The 49ers will host the Rams in an NFC West showdown in Week 13. The Rams are coming off a major upset over the Bears, while the 49ers are in a good place after a Monday night win over the Redskins. The dominant performance by the 49ers might spark a run as they look to hold on to the final Wild Card spot in the NFC. With playoff aspirations on the line, the 49ers are 10-point home favorites, according to OddsShark.

The over/under for the contest is 42 points. The 49ers are 6-1-1 in the last eight games against the spread, while the Rams are 5-6 against the spread this season. Both teams average around 24 points per game on offense, but the big difference between the teams is what they do on defense. The 49ers average just over 16 points allowed per game, while Rams are surrendering 23 points per contest.

The 49ers will host the Rams on Sunday at 4:05 p.m. ET on FOX.

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