The 49ers will travel to Arizona to face the Cardinals in the regular-season finale. The Cardinals have to win this game to keep their playoffs hopes alive, while the 49ers could use a win to possibly get home-field advantage throughout the playoffs. Due to both teams playing well and having so much on the line, this matchup is considered even, according to OddsShark. The over/under for the game is 42 points.
The Cardinals average 23.9 points per game while allowing 20 points on defense. The 49ers put up 25.5 points per game, but are giving up only 16.8 points to opposing teams. Arizona is 7-8 with the over/under, though just 3-4 at home. San Francisco is also 7-8 on the season with total points, but are 4-4 on the road. The Cardinals are 5-0-1 in the last six games against the spread, and are 10-4-1 on the season. The 49ers are 9-4-1 against the spread this season.