The Giants dropped their second game in two weeks to fall to 5-8, while the NFC East-leading Philadelphia Eagles improved to 8-5, making it mathematically impossible for New York to make the postseason.
The Chargers, meanwhile, improve to 6-7 to stay alive in the AFC wild card race.
The Giants defense looked lost for much of the game as San Diego piled up 388 of offense. Philip Rivers was sharp, throwing for 249 yards and three touchdowns. His first touchdown was a 42-yard bomb to Keenan Allen. After leaving breifly with a shoulder injury, Allen returned to the game to grab a second touchdown -- this one for four yards -- to put the Chargers up 17-0.
Danny Woodhead found the endzone just before the half as the Chargers headed into the locker room with a 24-point lead.
The Giants found the endzone twice during the second half, but continued making costly mistakes. Eli Manning threw a pair of interceptions in the game, upping his season total to 20.
Fantasy studs and duds
Allen was the big fantasy winner for the Chargers, making three receptions for 59 yards and two touchdowns. Ryan Mathews had a big day on the ground, rushing for 103 yards and a score.
Manning had 259 yards, one touchdown and the two picks. Hakeem Nicks broke out for 135 yards receiving, but still hasn't found the endzone this season.
Did they cover?
The Chargers came in favored by four points, according to Oddsshark.com, easily covering with the big win.
Thursday, Dec. 12, 8:25 p.m. ET: San Diego Chargers vs. Denver Broncos
Sunday, Dec. 15, 1 p.m. ET: Seattle Seahawks vs. New York Giants