Cornerback Brandon Browner is inactive for the second week in a row. He has been dealing with a hamstring injury the past two weeks and did not practice this week. Walter Thurmond will get the start, with Byron Maxwell working in the nickel slot. Chris Clemons is also out, still rehabbing from ACL surgery.
The good news for Seattle is that defensive end Cliff Avril is active. The big free agent signee will make his Seahawks debut this week after missing the opener.
The 49ers have a relatively healthy squad and had only one player on the injury report all week. Running back LaMichael James is out again as he works his way back from a knee injury. There are otherwise no big surprises for San Francisco.
Here's the complete inactive list for both teams:
DE Chris Clemons, CB Brandon Browner, S Jeron Johnson, DT Jordan Hill, OT Michael Bowie, OT Alvin Bailey, RB Christine Michael