Flowers was limited in practice this week for the Chiefs while he recovered from a right knee injury sustained against the Dallas Cowboys. He played the first three quarters of Thurday's game, but appeared to struggle covering Eagles' speedster DeSean Jackson on a 40-yard catch shortly before injuring his knee.
The Eagles are trying to make a late push and win Thursday's game, a task which will be considerably easier without Flowers on the field. The six-year cornerback has amassed 85 defended passes and 17 interceptions since arriving in the league in 2008.
Flowers was emotional on the field while he was attended to be trainers and has left for the locker room for further evaluation. Dunta Robinson will play in his absence.