49ers linebacker Patrick Willis has left San Francisco's game against the Colts on Sunday with a groin injury and will not return, according to the team's official Twitter account. Willis has five solo tackles today, as the 49ers trail, 13-7, at the time he was taken out of the game in the fourth quarter.
San Francisco was favored by 10 points at home against Indianapolis, but has struggled to move the ball on offense. Willis and the defense have mostly done their part, keeping the Colts to only a 1-yard Trent Richardson touchdown run early in the first quarter, but they will now need to step up in the absence of one of their greatest players.
Willis was drafted with the 11th overall pick in 2007 and has made the Pro Bowl in every season since, including five first-team All-Pro honors. He has missed only four games in his career and recorded 120 total tackles last year as San Francisco won the NFC.