Flowers suffered a knee injury prior to last week's game against the Philadelphia Eagles and ended up leaving the contest after the injury flared up during the game. Flowers practiced in a limited fashion this week but is unable to go during Sunday's game against the Giants.
The Giants have struggled so far this season, but they still possess a potentially dangerous passing attack with Eli Manning at quarterback.
The Chiefs' depth will be tested against the 0-3 Giants, with starting tight end Anthony Fasano and guard Jeff Allen all out with injuries. Allen has been frustrated by a calf injury and will be replaced by Geoff Schwartz, while Fasano continues to rehab from an ankle injury suffered in Week 1.
QB Tyler Bray, G Rishaw Johnson, CB Brandon Flowers, TE Anthony Fasano, TE Travis Kelce, G Jeff Allen, DT Jaye Howard.