NFL picks and predictions, Week 1: Patriots vs. Bills

Jim Rogash

The Patriots are the betting favorite in Week 1, and NFL experts expect them to take care of business against the Bills.

The Bills took awhile to name E.J. Manuel as Sunday's starting quarterback, but whether it was Manuel or Jeff Tuel, we knew Buffalo would be starting a rookie. The Patriots were likely going to be favored by oddsmakers regardless of who was under center and the experts agree.

More on this matchup: Pats Pulpit Buffalo Rumblings

New England was a unanimous selection among the eight CBS Sports NFL analysts. Even when those eight made their pick against the 9-1/2-point spread, all eight still went with New England. John Breech predicted New England to win by two touchdowns, 31-17. NFL senior columnist Pete Prisco predicted an even wider margin of victory for New England, as he has the Patriots winning 37-17.

Other pundits agree, including those at ESPN, where Mike Golic, Ron Jaworski, Seth Wickersham and Tom Jackson all picked New England.

The Patriots being a unanimous selection shouldn't come as too big of a surprise. New England is fresh off a 12-4 season, while the Bills finished 6-10. The fact that a rookie coming off knee injury will start for the Bills makes it even more likely for analysts to side with the Patriots.

New England opened as a five-point favorite, but the line has moved as high as 11 points, according to OddsShark.

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