Other Eastern Conference action will be held in Pittsburgh, where the Penguins will look to start-up a three-game winning-streak in their home-opener against the Toronto Maple Leafs.
In the Western Conference, the Vancouver Canucks and Calgary Flames will each be searching to win their first game of the season when they face-off at Rogers Arena, while Phoenix Coyotes will be hosting the Columbus Blue Jackets.
Here's a full look at the schedule and tonight's starting goaltenders:
Toronto Maple Leafs at Pittsburgh Penguins
7 p.m. ET | TV: TSN, RDS2, Root Sports Pittsburgh
Goalies: James Reimer (expected), Marc-Andre Fleury (confirmed)
Blog coverage: Pension Plan Puppets, PensBurgh
Calgary Flames at Vancouver Canucks
10 p.m. ET | TV: Sportsnet West, Sportsnet Pacific
Goalies: Miikka Kiprusoff (not yet announced), Cory Schneider (confirmed)
Blog coverage: The Cannon, Nucks Misconduct