It will be the second of three meetings between the two teams this season.
The first meeting was won by the Pens 2-1 by way of a shootout. Colin Greening managed the Senators lone goal, while James Neal recorded the other. Pittsburgh superstar Evgeni Malkin was credited with the game-winning goal.
The Penguins entered the last meeting between the two teams on a two-game losing streak, which will also be the case on Wednesday night. The club dropped consecutive games to the New Jersey Devils this past weekend by identical scores of 3-1.
With the exception of those two games, the Penguins had won five-of-six since last playing the Senators.
Ottawa will be playing in their second game in as many nights, as the club managed a 2-0 victory over the Buffalo Sabres on Tuesday.
The Senators have registered at least one point in three of their last four (2-1-1) and have managed to hold their opponents to two goals or fewer in 10 of 13 games played this season. On average, the team is allowing the fewest goals against per game in the league (1.69).
Pittsburgh will enter the evening averaging the sixth-most goals scored per game in the league (3.08).
Wednesday night's game is scheduled to begin at 7 p.m. ET and will be televised on TSN and ROOT.