It will mark the second of five meetings between the two teams this season.
When the teams last met on Jan. 22, the Devils managed a 3-0 victory. New Jersey goaltender Martin Brodeur held the Flyers scoreless on 24 shots, while the Devils offense was supplemented by goals from Travis Zajac, Ilya Kovalchuk and David Clarkson.
Both teams will be entering the night with two days off since their last contest.
The Devils lost to the Carolina Hurricanes on Tuesday night by a final of 4-2. However, New Jersey had won five-straight games going into that game and had held opponents to two goals or less in games over that span.
Philadelphia has registered points in five of their last six and will be entering Friday night off a 3-2 victory over the Winnipeg Jets. The game against the Devils will mark the half-way point of a six-game road trip, which still has stops in Montreal, Pittsburgh and New York (against the Islanders).
Ilya Bryzgalov (6-6-1; .913 save percentage and 2.49 GAA) has already been confirmed as the Flyers starter and will face Brodeur (6-2-2; .908 save percentage and 2.36 GAA).
Friday night's game is scheduled to begin at 7 p.m., ET and will be televised on CSN-PH and MSG PLUS.