The Eagles are a 3-point home favorite at most sportsbooks, but the big storyline is Andy Reid's return to Philadelphia. The longtime Eagles coach's new team is off to a 2-0 SU and 1-1 ATS start after blowing out Jacksonville in Week 1 and beating Dallas, 17-16, last week.
The question about whether or not his replacement's offense could work in the NFL has seemingly been put to rest with the Eagles ranking second in the NFL in total yards (477 per game) and third in the league in scoring (31.5 points per game) through the first two weeks of the season.
But while Chip Kelly's offense is rolling, the defense is once again a concern, as it was last year, allowing 27 points to Washington in a road win and 33 points to San Diego in a road loss.
Alex Smith has solidified the quarterback position for the Chiefs, throwing two touchdown passes and no interceptions in both of Kansas City's first two games.
This game will likely be decided by which team can control the tempo. Kansas City isn't built for a shootout and could end up falling behind if Philadelphia gets its track-meet offense going.
But on the other hand, the Chiefs have looked great on defense so far this year, and if they can slow the game down and grind out the clock with their power running game, they will have the upper hand.
It could easily go either way, but we lean toward the Chiefs in this one. Philadelphia's defense hasn't shown the ability to prevent opposing offenses from setting the tone yet, and Kansas City will undoubtedly be motivated to get its head coach a win and some revenge over the team that fired him.