12-seeds are 6-1 ATS in seven games against 4-seeds since 2006.
12-seed North Dakota State will try to keep that streak going as a 3-point underdog Saturday against the 4-seed San Diego State Aztecs.
In Saturday's other West region game, 2-seed Wisconsin is a 5-point favorite against 7-seed Oregon.
North Dakota State extended its winning streak to 10 with Thursday's 80-75 upset win over Oklahoma. Lawrence Alexander went off for a season high 28 points in the win.
The Bison are 5-2 ATS over their last seven games and 15-1 SU over their last 16. The total has gone UNDER in nine of North Dakota State's last 12 games.
San Diego State is 24-2 SU in its last 26 games as the betting favorite and 6-3 ATS in its last nine games as the favorite. With the second best defense in the nation, the Aztecs have gone UNDER the total in four of their last five games.
In failing to cover the spread in its 73-69 win over New Mexico State, SDSU fell to 1-4 ATS in its last five tourney games.
North Dakota State vs. San Diego State tips off at 6:10pm ET in Spokane to get the college basketball betting lines rolling. Before that one is over, the betting matchup of Oregon vs. Wisconsin will get started in Milwaukee at 7:45pm.
Oregon enters Saturday's game against Wisconsin on a 9-1 SU and 7-2-1 ATS run over its last 10 games. The Ducks are 9-2 ATS in their last 11 games as the betting underdog and 4-0 ATS in their last four NCAA Tournament games. The Ducks hope to end an 0-10 SU streak of 7-seeds facing 2-seeds.
Wisconsin crushed American University 75-35, covering the spread for just the second time in its last six games. The Badgers will have another strong crowd Saturday playing in their home state. Wisconsin has been upset by 7-seeds in the NCAA Tournament twice since 1997.
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