The 11-seed Dayton Flyers are 8-3 ATS and 7-4 SU in their last 11 games as the betting underdog and they play the same role Thursday in Sweet 16 betting.
Dayton faces 10-seed Stanford, while later in the evening, the 1-seed Florida Gators take on the 4-seed UCLA Bruins as a 4.5-point favorite.
Two days after pulling off a thrilling one-point upset over Ohio State, Dayton did it again against Syracuse, topping the Orange, 55-53, as an 8.5-point underdog.
The Flyers are now 4-2 SU and ATS in their last six games as an underdog. Overall, Dayton is 6-1 SU and ATS over its last seven games.
Stanford has also collected two upsets to earn its trip to the Sweet 16, beating Kansas 60-57 as a 6-point underdog on Friday. The Cardinal are 5-1 SU and 3-2-1 ATS over their last six games.
[ Stanford vs Dayton live odds, trends | Florida vs UCLA betting stats, matchup details ]
The total has gone UNDER in six of Stanford's last seven games including each of its last four. In the only other 11-seed vs. 10-seed matchup since 1996, 11-seed VCU beat 10-seed Florida State.
Thursday's South Region action kicks off at the FedExForum in Memphis, Tennessee with Dayton vs. Stanford at 7:15 p.m. ET. Shortly afterward is the UCLA vs. Florida betting matchup at 9:45 p.m.
Florida made quick work of Pittsburgh in a 61-45 blowout win, improving to 28-0 SU over its last 28 games and 6-2 ATS over its last eight. The Gators are a perfect 6-0 SU in their last six Sweet 16 games with a 4-2 ATS record over that stretch.
Florida is 3-0 SU and ATS against the Bruins in three tournament meetings since 2006.
UCLA picked up a 77-60 blowout win over Stephen F. Austin on Sunday to improve to 5-0 SU and ATS over its last five games. The Bruins are 4-1 SU and ATS in their last five games as an underdog.
UCLA has struggled in the Sweet 16 with a 1-7 ATS record since 1997.
See the latest March Madness odds, matchup reports and trends on every game and follow live lines and your bracket picks with the free OddsShark.com odds app.