Uruguay is playing in a tough group with Italy and England while Costa Rica is the major long shot in the group.
The Central American nation not only has the worst World Cup betting odds to win their group, but have the worst overall odds to win the entire tournament.
Still, with the defense they have they can surprise Uruguay and take a point away from this match with a draw.
Sportsbooks monitored by OddsShark.com has Uruguay as the big World Cup odds favorite in the match posted at -225 with Costa Rica at +800 and a draw line of +350.
Costa Rica qualified for Brazil because of their defense, which held their opponents scoreless for an amazing 476 minutes in the qualification process. OK, so they face a tougher Uruguay offense in the main tournament, but they will step up in the match on that side of the pitch.
Costa Rica does have a tall task with the likes of Diego Forlan, Edinson Cavani, and Luis Suarez, who lead the Uruguay attack. Suarez is match fit after a minor injury issue and he led the England Premier League in goals this season playing for Liverpool.
However, will he play in this match? The two tougher matches are facing Italy and England and Uruguay may sit their star.
Uruguay's defense has played well in their last two friendly matches, but it is still the weakness of the squad. While Costa Rica does not have an attacking offense Joel Campbell from Fulham and Bryan Ruiz from PSV Eindhoven on loan from Fulham are a solid FW duo that may, and will, give problems to the Uruguay defense.
Costa Rica finished a surprising second to the USA in the CONCACAF qualifying process and they will surprise Uruguay in their Group D opener. While they have not been impressive in their World Cup tune-ups this year they are dangerous and one of the main reasons is they have absolutely no pressure on them.
The defense for Costa Rica will play well and Ruiz or Campbell will score and leave this match with a draw.
Prediction: 1-1 draw