Roma drew level on points with city rivals Lazio as Zdenek Zeman made a successful return to Pescara.
Mattia Destro scored the only goal of the game after five minutes to condemn Pescara to their third successive defeat. It was a stern test for new coach Cristiano Bergodi, who picked up from where Giovanni Stroppa left off - with a loss. Roma move into joint fifth position, while their opponents prop up the table.
Destro was first to react after Mattia Perin couldn't hold Francesco Totti's venomous free kick, and he registered his second goal in a Roma shirt. Speaking of shirts, this time Destro kept his on, learning from his Palermo mistake earlier in the season.
Poor decision making from Mauro Goicoechea almost let Francesco Modesto in on 20 minutes, as the young goalkeeper hesitated before coming for a loose ball. The Uruguayan custodian redeemed himself and got the ball clear.
A good save from Perin denied Destro a second goal on 32 minutes. The frontman met Totti's inch perfect cross and powered a header at goal, only to see it palmed over. Marquinhos ballooned over the resulting corner from a few yards out.
The visitors laid siege to the Pescara goal in the first five minutes of the second half. Christian Terlizzi stood firm to stop Destro from turning him. Moments later, the frontman just missed getting on the end of an Ivan Piris ball.
After Alessandro Florenzi fired wide of the post, Destro hooked a shot wide when all alone in the box. The former Genoa and Siena man wrongly thought he was offside, as he and Pablo Daniel Osvaldo were both left unmarked. Osvaldo was offside, but Destro wasn't. Perin denied the frustrated forward once again, saving a low drive with his legs.
Ten minutes in, Juan Fernando Quintero was booed off the pitch by his own fans as the ineffective Colombian made way for Vladimir Weiss.
Just short of the hour, Perin was rooted to the spot and could only watch as Totti curled a shot wide of the far post. On the hour, Federico Balzaretti crossed for Destro to spurn another chance and head wide.
Roma lost Florenzi to a hamstring injury and Destro was withdrawn, following a studs-up challenge by substitute Danilo Soddimo. The Pescara man was rightly booked and lucky not to be dismissed.
Totti was the driving force behind Roma going forward and saw a long range effort parried to safety. Pescara suddenly awoke from their slumber and came into the match during the last ten minutes.
Goicoechea went down awkwardly from a Terlizzi challenge after catching a routine cross, but was alright to continue.
The home side's best chance came on 83 minutes. Matti Lund Nielsen's shot ricocheted off the arm of Marquinhos and the ball fell nicely to the feet of Elvis Abbruscato in the box, but his shot hit the Roma defence. The visitors took the ball down the other end, only for Marquinho to slip at the crucial moment, which saw the chance go begging.
In the final minutes, the energetic Weiss blazed over from the edge of the box, then played Abbruscato in, only to see his shot deflect wide.
Pescara: Perin; Romagnoli, Terlizzi, Bocchetti; Balzano, Bjarnason, Nielsen, Togni, (Soddimo 74) Modesto; (Caprari 80) Quintero, (Weiss 55) Abbruscato
Roma: Goicoechea; Piris, Marquinhos, Castan, Balzaretti; Pjanic, Bradley, Florenzi; (Marquinho 69) Destro, (Perrotta 78) Osvaldo, (Tachtsidis 87) Totti
Goal: Destro 5 (R)