They may have lost on all four of their last visits here, but for the first time this season, Roma have enjoyed back-to-back victories. The win sees the side from the capital move up to fifth in the standings, while Genoa stay ninth.
The Giallorossi demonstrated both the Jekyll and Hyde traits they've become accustomed to under Zdenek Zeman when they conceded twice in the first 15 minutes.
Juraj Kucka's right-foot strike put Genoa one up after six minutes. On the quarter hour mark, Bosko Jankovic acrobatically volleyed against the bar. Roma's defenders were caught ball watching and Kucka teed Jankovic up to finish - albeit rather scruffily at the second attempt.
Francesco Totti reduced the arrears, with a quick turn and shot from an angled position into the bottom corner.
The strike, Totti's 217th puts him in third place outright in the all-time scoring charts behind Silvio Piola and Gunnar Nordahl. He only needs eight more goals to tie level with Nordahl.
The visitors drew level on the stroke of half time. Ivan Piris crossed for Pablo Daniel Osvaldo to volley home from ten yards.
Osvaldo claimed his second ten minutes into the second half. The temperamental Italian rose highest from a pinpoint corner to head home his fifth goal in four Serie A games. Osvaldo has scored in every game he's been a part of for Roma so far this season. Some have started to make comparisons with the legendary Gabriel Batistuta.
Genoa lost former Roma man Marco Borriello to a sprained ankle and had to play the final 15 minutes with ten men, having used all three substitutions.
Roma capitalised on having the extra man and wrapped the game up seven minutes from time. Totti's through ball to Miralem Pjanic was blocked, but Erik Lamela was on hand to bend the ball past Sebastien Frey at the far post.
Genoa fans whistled their players off the pitch at the end.
Genoa: Frey; Canini, Bovo, Antonelli (Melazzi 69), Granqvist; Moretti, Jankovic, Kucka, Seymour (Bertolacci 62); Borriello, Jorquera (Immobile 54)
Roma: Stekelenburg; Piris, Marquinhos, Castan, Balzaretti; De Rossi, Tachtsidis, Florenzi (Pjanic 77); Lamela, Osvaldo (Bradley 88), Totti
Goals: Kucka 7 (G), Jankovic 15 (G), Totti 27 (R), Osvaldo 44, 55 (R), Lamela 83 (R)