Schalke 04 have been a bit ravaged by injuries, while their first choice defensive midfielder is cup tied, but they have still selected a relatively strong (although makeshift) lineup to face Inter Milan. Peer Kluge suffered an injury in the team's last league match that keeps him out of this one, along with Mario Gavranović. Klass-Jan Huntelaar is still out, so Gavranovic's injury could hurt Schalke considerably. Edu will start in place of those two players up top.
With some concerns in defense, either Joel Matip or Kyriakos Papadopoulos will have to fill in as a defender. Both are defensive midfielders by trade who have spent time at central defense. It's not 100% clear who will make the move back.
Whoever plays left midfield, whether it's Jose Jurado or Alexander Baumjohann, will be playing slightly out of position. Both have played that position on many occasions and are capable, but against a side like Inter, Schalke would probably prefer to have a true wide player to exploit their deficiencies. Here is the full lineup.
Schalke 04 lineup (projected 4-4-2): Neuer; Sarpei, Popadopoulos, Höwedes, Uchida; Jurado, Baumjohann, Matip, Farfan; Raul, Edu