Real Madrid and Borussia Dortmund have a number of key players facing battles to get fit before their big match. Two of the other three groups also feature their top two teams facing off on Wednesday.
All eyes will be on Group D this Wednesday, just like they have been during the previous two rounds of UEFA Champions League play. Borussia Dortmund and Real Madrid, who both stopped Manchester City from winning in previous rounds, face off for the top spot in the group while City goes away to Ajax.
Two other groups feature the two teams on top of the table facing off against each other. In Group B, Arsenal meet their toughest test yet when they host Schalke, who are coming off a massive derby win over Dortmund in the Bundesliga. In Group C, AC Milan might be considered underdogs away to Malaga, who have six points from their first two matches.
In Group A, anything but wins for the two favorites would be a surprise. FC Porto host Dynamo Kiev, while Paris Saint-Germain will expect victory away to Dinamo Zagreb.
Schedule (all times ET)
Zenit St. Petersburg vs. Anderlecht - 12 p.m.
Malaga vs. AC Milan - 2:45 p.m.
Dinamo Zagreb vs. Paris Saint-Germain - 2:45 p.m.
FC Porto vs. Dynamo Kiev - 2:45 p.m.
Arsenal vs. Schalke 04 - 2:45 p.m.
Montpellier vs. Olympiakos - 2:45 p.m.
Ajax vs. Manchester City - 2:45 p.m.
Borussia Dortmund vs. Real Madrid - 2:45 p.m.