Included in the Spurs lineup will be Gareth Bale, returning from paternity leave to face his former club. The Saints will know all about the dangers posed by the Welshman, and will have to stifle his creativity and goalscoring in order to get something from the game.
One interesting statistic to watch is that Tottenham have scored more of their goals than any other club in the second half, whereas Southampton have conceded more than any other club in the second half. That in mind, Saints fans shouldn't be celebrating too early if they do take the lead. Although with Southampton having been forced to come from behind to earn all of their points this season, they will be used to being in the reverse position too.
Southampton injuries and suspensions
Out: Gaston Ramirez (thigh), Frazer Richardson (groin), Jack Cork (knee). In doubt: Tadanari Lee (elbow), Luke Shaw (illness).
Tottenham Hotspur injuries and suspensions
Southampton's record signing Gaston Ramirez is again unavailable as he continued his recovery from a thigh injury. Luke Shaw, meanwhile, has recovered from an illness and could make his Premier League debut.
Tottenham's Gareth Bale returns from paternity leave to face his former club, but Spurs are struggling with a host of injury problems, with Parker, Assou-Ekotto and Kaboul certain to miss out and Adebayor, Dembele and Dawson struggling.
Match Date/Time: 3 p.m. Local, 10 a.m. E.T.
Venue: St. Mary's, Southampton, England
TV: Fox Soccer Plus (U.S.)
Online: Fox Soccer 2Go (U.S.)