Gonzalo Arroyo Moreno
Real Madrid and Barcelona both take on third division sides, while Sevilla and Espanyol contest the best tie of the round.
The luck of the draw did not stick the viewing public with a random autumn Clasico double in the Copa Del Rey. Such a shame. Real Madrid and Barcelona are unlikely to get through the tournament without meeting each other, as per usual, and both have relatively straightforward draws for the fourth round.
Barcelona play on Tuesday, and are likely to rest all of their first choice players for a match away to third tier side Alaves. They were in La Liga as recently as 2006, but lasted just one season in the top flight and three seasons in the Segunda before heading down to the Segunda Division B in 2009.
Jose Mourinho's side are in a similar situation, against Alcoyano, who were relegated from the Segunda last season. Real Madrid Castilla, like Barcelona B, are a mid-table Segunda team, meaning that the Madrid reserves will be favored to progress in Copa Del Rey.
The fourth round draw produced three matches between La Liga sides, with the best coming on Thursday when Espanyol take on Sevilla. Granada travel to Real Zaragoza during one of Wednesday's early games, while Mallorca take on Deportivo La Coruña in Thursday's nightcap.
Copa Del Rey ties are home and away, decided by aggregate score. The return legs are in just under a month, during the week of November 26.
Schedule (all times ET)
Llagostera vs. Valencia - Tuesday, 3 p.m.
Alaves vs. Barcelona - Tuesday, 5 p.m.
Almeria vs. Celta Vigo - Wednesday, 3 p.m.
Cacereno vs. Malaga - Wednesday, 3 p.m.
Jaen vs. Atletico Madrid - Wednesday, 3 p.m.
Real Zaragoza vs. Granada - Wednesday, 3 p.m.
Las Palmas vs. Rayo Vallecano - Wednesday, 4 p.m.
Alcoyano vs. Real Madrid - Wednesday, 5 p.m.
Eibar vs. Athletic Bilbao - Thursday, 7 a.m.
Valladolid vs. Real Betis - Thursday, 12 p.m.
Melilla vs. Levante - Thursday, 1 p.m.
Cordoba vs. Real Sociedad - Thursday, 2 p.m.
Ponferradina vs. Getafe - Thursday, 2 p.m.
Sevilla vs. Espanyol - Thursday, 2 p.m.
Sporting Gijon vs. Osasuna - Thursday, 2 p.m.
Deportivo La Coruña vs. Mallorca - Thursday, 4 p.m.