Andre Villas-Boas has dropped Clint Dempsey and opted for a 4-4-2 in a surprise for Spurs, while Arsenal start with Olivier Giroud up front.
In a surprise move, Tottenham Hotspur boss Andre Villas-Boas has gone 4-4-2 for the North London Derby as he starts with both Emmanuel Adebayor and Jermain Defoe, with Clint Dempsey dropped after some recent disappointing form. Gareth Bale and Aaron Lennon start out wide in what could be a hugely attacking move for the away side.
Arsenal, meanwhile, start with a 4-3-3 with Olivier Giroud flanked by Lukas Podolski and Theo Walcott. Thomas Vermaelen continues at left-back, while Aaron Ramsey and Alex Oxlade-Chamberlain are on the bench. The Gunners also welcome back Wojciech Szczesny in goal.
Arsenal (4-3-3): Wojciech Szczesny; Bacary Sagna, Per Mertesacker, Laurent Koscielny, Thomas Vermaelen; Jack Wilshere, Mikel Arteta, Santiago Cazorla; Theo Walcott, Olivier Giroud, Lukas Podolski. Subs: Vito Mannone, Andre Santos, Alex Oxlade-Chamberlain, Aaron Ramsey, Francis Coquelin, Andriy Arshavin, Carl Jenkinson.
Tottenham(4-4-2): Hugo Lloris; Kyle Walker, William Gallas, Jan Vertonghen, Kyle Naughton; Aaron Lennon, Sandro, Tom Huddlestone, Gareth Bale; Emmanuel Adebayor, Jermain Defoe. Subs: Brad Friedel, Clint Dempsey, Michael Dawson, Gylfi Sigurdsson, Jake Livermore, Andros Townsend, Tom Carroll.