Manchester United have already qualified from Group H and have named an inexperienced squad to travel to Galatasaray, who are fighting to progress to the knockout stages.
Manchester United travel to Istanbul to face Galatasaray having already qualified for the first knockout round of the Champions League, but Gala boss Fatih Terim is not taking anything for granted.
When posed with the prospect of facing an inexperienced United lineup, the coach responded: "I don't understand why the media are focusing on Manchester United's Istanbul squad. We shouldn't dwell too much on it because it's still Manchester United who you're facing in the end."
Ferguson has left out most of his big names for the trip, including Wayne Rooney, Patrice Evra and Rio Ferdinand. With his team already through, the atmosphere that produced the infamous 1993 "Welcome to Hell" match will be far more bearable, but Terim is gearing up his squad for what he insisted was "one of the most important games in Galatasaray's history."
Galatasaray injuries and suspensions
Out: Tomas Ujfalusi (knee) In doubt: Johan Elmander, Aydin Yilmaz (flu).
Manchester United injuries and suspensions
Out: Shinji Kagawa (knee), Nemanja Vidic (knee.)
Galatasaray will be without long-term absentee Tomas Ujfalusi, while Johan Elmander is not ready to return to action either. Aydin Yilmaz has a touch of flu, but Fatih Terim says it will not stop Gala from using him "if needed."
Shinji Kagawa has had a setback to his recovery from injury for United and faces a further four weeks out, while Nemanja Vidic is still absent. Phil Jones does however return for the Red Devils, and will start.
Match Date\Time: Tuesday, 9:45 p.m. local, 7:45 p.m BST, 2:45 p.m ET
Venue: Türk Telekom Arena, Istanbul, Turkey
TV: Fox Soccer Plus (U.S.), Sky Sports 4 (U.K.), Sportsnet World (Canada), Star TV (Turkey).
Online: Fox Soccer 2Go (U.S.)