Jose Mourinho was booed by Real Madrid fans as their team cruised to a comfortable win, while Malaga only just scraped through against third-tier Caraceno.
Malaga 0-1 Caraceno (Malaga 4-4 Caraceno aggregate; Malaga go through on away goals)
Manuel Pellegrini avoided having another embarrassing Copa Del Rey exit on his hands after just scraping through against third-tier Caraceno. The manager who famously oversaw Real Madrid's disastrous humiliation at the hands of Alcorcon saw winger Chapi give the Spanish minnows a chance of victory, and had to endure a nervy moment when they scored again, only for the goal to be ruled out through offside. In the end, Malaga hung on to only lose 1-0 - meaning they go through on away goals after their 4-3 victory in the first leg.
Real Madrid 3-0 Alcoyano (Real Madrid 7-1 Alcoyano aggregate)
Jose Mourinho sent out a number of youngsters to get the job done against Alcoyano, including Denis Cherysev, but it was Jose Callejon and Angel Di Maria who got the goals in a comfortable victory. The match was notable, however, for Mourinho attracting some jeers from his home supporters in the wake of their disappointing league campaign.
Rayo Vallecano 0-0 Las Palmas (Rayo Vallecano 0-1 Las Palmas aggregate)
Rayo Vallecano suffered defeat at the hands of second-tier Las Palmas after, incredibly, having their goalkeeper sent off in both legs of the tie. A 0-0 draw was enough for the islanders to progress after winning the first leg.
Betis picked up where they left off after their weekend triumph over Real Madrid by overturning the deficit from the first leg to beat Valladolid 3-0 and progress to the next round.
Osasuna 2-0 Sporting Gijon (Osasuna 2-1 Sporting Gijon aggregate)
Osasuna needed a 2-0 win to progress after losing the away leg, and did exactly that to ensure their progress thanks to goals from Joseba Llorente and Ruben.
Real Sociedad 2-2 Cordoba (Real Sociedad 2-4 Cordoba aggregate)
Real Socieded needed a 2-0 win to take the game to extra time, and Antoine Griezmann gave them hope early on by giving them a 1-0 lead, but second-tier Cordoba struck back with a brace to make their task impossible. A late consolation from Agirretxe was not enough for the hosts.