Two teams with key players missing and both needing a win. It's either a recipe for a wide open and entertaining match or a snooze fest as both sides attempt to be careful, afraid to open up too much and give their opponent a chance to take advantage. We'll have to see.
The big changes for Benfica are in the midfield where André Almeida replaces the suspended Nemanja Matic while Enzo Peréz slots in the center of the midfield for the injured Carlos Martins.
Spartak also has their adjustments caused by injuries. Aiden McGeady and Emmanuel Emenike are both out, so Ari starts up top as the lone striker, while Kirill Kombarov takes over in the midfield.
Benfica starting lineup (4-1-3-2): Artur Moreas; Maxi Pereira, Ezequiel Garay, Lorenzo Melgarejo, Jardel; André Almeida, Enzo Peréz, Ola John, Eduardo Salvio; Lima, Rodrigo.
Spartak Moscow lineup (4-2-3-1): Artem Rebrov; Juan Insaurralde, Nicolás Pareja, Evgeni Makeev; Kim Källström, Rafel Carioca, José Manuel Jurado, Kirill Kombarov, Dmitri Kombarov, Diniyar Bilyaletdinov; Ari.