Manchester United have named a very attacking team, while taking the opportunity to rest a couple of players for the weekend. They have a five-point cushion on top of their group, so they can probably afford to take this one a bit lightly. Rio Ferdinand sits out and makes way for Chris Smalling, who will start for the first time this season. Antonio Valencia is playing left back, while Anderson and Ryan Giggs make up the Red Devils' midfield. Robin van Persie is rested.
Braga have some players back from injury and some new fitness issues to deal with as well, so their team is very different than the one that faced United in the last round.
Braga starting lineup (4-2-3-1): Beto; Elderson, Nuno Andre, Douglao, Ruben Amorim; Custodio, Hugo Viana; Leandro Salino, Ruben Micael, Alan; Eder
Kickoff is at 2:45 p.m. ET, and the game can be seen on FOX Soccer in the U.S. and Sky Sports 2 in the U.K.