The England international starts as a striker ahead of an attacking midfield three of Santi Cazorla, Lukas Podolski, and Alex Oxlade-Chamberlain. Mikel Arteta and Jack Wilshere begin as expected in the double pivot just behind them.
Wigan meanwhile continue in their 3-4-3 formation despite their injuries at centre-back, with Maynor Figueroa, David Jones, and Emerson Boyce making up an unconventional back three. Arouna Kona, Shaun Maloney, and Franco Di Santo make up a dangerous front three for the hosts.
Arsenal (4-2-3-1): Wojciech Szczesny; Bacary Sagna, Per Mertesacker, Thomas Vermaelen, Kieran Gibbs; Mikel Arteta, Jack Wilshere; Alex Oxlade-Chamberlain, Santiago Cazorla, Lukas Podolski; Theo Walcott.