Liverpool manager Kenny Dalglish has chosen to start the game with a front two pairing of Luis Suarez and Andy Carroll, while Spanish left-back Jose Enrique drops out of the side. Third choice goalkeeper Brad Jones starts asPepe Reina and Doni are both suspended.
Meanwhile Everton boss David Moyes, currently celebrating a decade as Blues boss, includes the returning Tim Cahill, Nikica Jelavic, Sylvain Distin and Leighton Baines, who all sat out the Easter Monday win over Sunderland.
Liverpool Starting Lineup (4-4-2): Brad Jones; Glen Johnson, Jamie Carragher, Martin Skrtel, Daniel Agger; Jordan Henderson, Jay Spearing, Steven Gerrard, Stewart Downing; Luis Suarez, Andy Carroll.
Substitutes: Peter Gulasci, Jose Enrique, Maxi Rodriguez, Dirk Kuyt, Jonjo Shelvey, Martin Kelly, Craig Bellamy.
Everton Starting Lineup (4-4-1-1): Tim Howard; Phil Neville, John Heitinga, Sylvain Distin, Leighton Baines; Leon Osman, Darron Gibson, Marouane Fellaini, Magaye Gueye; Tim Cahill; Nikica Jelavic.
Substitutes: Marcus Hahnemman, Tony Hibbert, Phil Jagielka, Denis Stracqualursi, James McFadden, Seamus Coleman, Victor Anichebe.
Kick off is at 7:30am ET, and 12:30pm UK time, and is available on Fox Soccer Channel (USA), Sportsnet World (Canada) and ESPN (UK).
For more on the game check out our Liverpool site, Anfield Asylum, and our Everton site, Royal Blue Mersey.