The Flying Donkeys play host to the high flying Eagles, who will be looking to maintain their 100% start to the campaign.
The visitors have won five of their last away games against Chievo Verona, including a 3-0 victory back in January.
Thus far, the Lazio rearguard has stood firm in its two Serie A tests, while Chievo have been on both ends of a 2-0 scoreline.
However, Lazio will have to keep their minds at the Bentegodi and not let thoughts drift towards Thursday’s Europa League tie at White Hart Lane, if they want to emerge with all three points.
Chievo tactician Mimmo Di Carlo has made his side hard to break down, but at the other end, must do without injured frontman Alberto Paloschi.
In contrast, Lazio have selection problems in defence, as Senad Lulic looks set to join Stefan Radu on the sidelines, after the Bosnian picked up a knock on international duty. With Modibo Diakite unlikely to be considered as he stalls over a new contract, it could open the door for Michael Ciani to make his Biancocelesti debut.