The Italian cautioned that while Aguero had fully healed, he was lacking match sharpness, but could still feature. "He has a chance", Mancini told a press conference at the Santiago Bernabeu. "Probably he is not 100 percent because he didn't play since the injury but the feeling at this moment is good."
Aguero has not played since he was stretchered off after receiving an injury after a tackle from Nathaniel Clyne in City's opening game of the season against Southampton.
The Argentine will be no stranger to facing Real Madrid, having previously played for local rivals Atletico Madrid, although he will hope that his new club can fare better, having suffered eight defeats and three draws in the eleven Madrid derbies in which he played.