Andre Villas-Boas continues with a 4-4-2 for Tottenham as he starts Emmanuel Adebayor and Jermain Defoe up front again as his side take on Reading.
Aaron Lennon starts on the right, while Gareth Bale, currently serving his controversial suspension, is replaced by Gylfi Sigurdsson on the left. Sandro and Moussa Dembele are in central midfield. Kyle Naughton continues at left-back in the Tottenham defence, while Tom Huddlestone, Scott Parker, Jake Livermore and Clint Dempsey are all on the bench.
Reading meanwhile continue as expected, with Pavel Pogrebnyak up front ahead of Danny Guthrie and Jimmy Kebe and Jobi McAnuff providing support from the wings.
Tottenham Hotspur (4-4-2): Hugo Lloris; Kyle Walker, Michael Dawson, Jan Vertonghen, Kyle Naughton; Sandro, Moussa Dembele, Aaron Lennon, Gylfi Sigurdsson; Emmanuel Adebayor, Jermain Defoe.
Reading (4-4-1-1): Adam Federici; Chris Gunter, Ian Harte, Adrian Mariappa, Alex Pearce; Jem Karacan, Mikele Leigertwood, Jimmy Kebe, Jobi McAnuff; Danny Guthrie; Pavel Pogrebnyak.