The home side will, of course, be heavy favourites, but have a swathe of injury problems to some of their players, although they will be boosted by a spirited second-half display during their recent 2-1 defeat to Chelsea in the Premier League. West Ham boss Sam Allardyce, meanwhile, will be hoping he can maintain his good record against his arch-nemesis Arsene Wenger.
West Ham have injury problems of their own, and will look to pick up their form as soon as possible to avoid getting sucked into a relegation dogfight. It is not known whether any of the Hammers' recent new signings will feature - Wellington Paulista is not expected to be ready to start, even though West Ham are light on strikers with Andy Carroll out and Marouane Chamakh ineligible, although the Brazilian could have a place on the bench.
Arsenal injuries and suspensions
West Ham United injuries and suspensions
Both sides have a few injury concerns for the game, with Arsenal losing Gervinho to the Africa Cup of Nations, while Mikel Arteta, Tomas Rosicky, Francis Coquelin and Lukasz Fabianski all remain out. Abou Diaby, an inclusion in the Gunners' starting line-up of late, is also a doubt and will undergo a late test.
West Ham also suffer from international duty as Modibo Maiga is away. Marouane Chamakh is also ineligible to play against his parent club, while Andy Carroll is still out along with George McCartney and James Collins.
Match Date\Time: Wednesday, 7:45 p.m. local, 2:45 p.m. ET
Venue: Emirates Stadium, London, England
TV: Fox Soccer Channel (U.S. English), Fox Deportes (U.S. Spanish), Sportsnet World (Canada)