Southampton have been one of the season's surprise packages so far, with Mauricio Pochettino slowly but surely erasing the bizarrely angelic apparition of ex-boss Nigel Adkins which still haunts St Mary's. The Saints have won their last three games and have moved up to fourth in the league, though have a tough test away at Old Trafford on Saturday.
David Moyes' side have been rather less impressive so far, having relied on a brace from teenage winger Adnan Januzaj to beat bottom side Sunderland before the international break. The Red Devils are now up into the top half of the table, currently four points adrift of the side they host this weekend.
United will certainly be without long-term absentee Darren Fletcher, while Rio Ferdinand and Tom Cleverley face fitness tests to determine their availability. Southampton are comparatively much healthier, with only Pablo Osvaldo doubtful.
Manchester United injuries and suspensions
Out: Darren Fletcher (illness). In doubt: Rio Ferdinand (groin), Tom Cleverley (calf).
Southampton injuries and suspensions
Out: None. In doubt: Pablo Osvaldo (ankle).
Southampton: Kelvin Davis; Luke Shaw, José Fonte, Dejan Lovren, Nathaniel Clyne; Morgan Schneiderlin, Victor Wanyama; Steven Davis, Pablo Osvaldo, Adam Lallana; Ricky Lambert.
Match Date/Time: Saturday, 3 p.m. local, 10 a.m. ET
Venue: Old Trafford, Manchester, England
TV: NBC Sports Network, Mun2 (U.S.), RDS, TSN (Canada).
Online: NBC Live Extra (U.S.)