Chelsea will look to build upon their comfortable position in the Champions League group stages and shake off their defeat at Newcastle as they take on Schalke 04 at Stamford Bridge.
José Mourinho will make changes due to fitness and form from the game at St. James' Park - Fernando Torres will miss out through injury, while Juan Mata is likely to find himself on the bench at best.
Schalke, meanwhile, will look to build on their dangerous away form in the Bundesliga, with six wins and no defeats in their last seven games away from Gelsenkirchen.
Chelsea's 3-0 win at Schalke gave them a commanding position in the group after their shock loss to Basel, and a win here should see them take complete control. But Schalke - and Chelsea - are both capable of springing a surprise.
Chelsea injuries and suspensions
Out: Fernando Torres (thigh), Ryan Bertrand, Marco van Ginkel (cruciate).
Schalke injuries and suspensions
Chelsea have new knocks to Fernando Torres and Ryan Bertrand only, while Schalke's injury list grows with Leon Goretzka's tonsilitis.
Match Date/Time: Wednesday, 6th November 2013, 7:45 p.m. local, 2:45 p.m. ET
Venue: Stamford Bridge, London, England
TV: FOX Soccer Plus (U.S.), Sky Sports 2 (U.K.), Sportsnet World (Canada), Sky Sport 3 (Germany.)
Online: FOX Soccer 2Go (U.S.), Sky Go (U.K.), Sportsnet World Online (Canada.)