Vincenzo Montella only made one change from the side that beat Lazio last week, Alberto Aquilani returning from suspension to replace Giulio Migliaccio. Davide Ballardini made three changes from the team that lost to Milan, bringing in Juraj Kucka and Ciro Immobile in place of Cesare Bovo and Marco Borriello and handing Alexandros Tzorvas his first action this season in goal after Sebastien Frey suffered an injury.
Fiorentina began the brighter of the sides and had no trouble passing the ball around their midfield and pushing Genoa back into their half however it was the Grifone who had the first half-chance, Andrea Bertolacci taking advantage of some hesitant Fiorentina defending but his 20-yard effort sailed well over Emiliano Viviano's crossbar.
The Viola midfield continued to dominate proceedings and Juan Cuadrado was a real live-wire down the right hand side, causing Genoa all kinds of problems. His drilled low ball into the box found Alberto Aquilani but the finish was poor, flying well over the bar.
Adem Ljajic should've given Fiorentina the lead, a glorious pass from Stevan Jovetic setting him through one-on-one with Alexandros Tzorvas, however the Serbian poked it wide withthe Greek goalkeeper onrushing.
Fiorentina continued to pile on the pressure, with Cuadrado causing Emiliano Moretti on the left of the Genoa defence nightmares, however it was some neat interplay between Ljajic and Jovetic which would carve out the next chance, Jovetic shooting weakly at Tzorvas after receiving the ball in the box.
Just after the half hour mark, Fiorentina got the goal that their pressure deserved. Adem Ljajic got the better of Daniele Portanova and made it to the byeline on the right. His cutback found Alberto Aquilani who couldn't miss from a couple of yards.
The Viola continued to dominate until half time, David Pizarro's effort hitting the crossbar and the teams went in at 1-0 with Genoa having not registered a single shot on target.
The changes appeared to work, with Genoa getting a lot more time on the ball than at any time in the first half and actually coming close to forming attacks. Juan Vargas provided them with their first shot on target, his free kick going straight at Viviano.
15 minutes after the break and Genoa had an equaliser that looked like a ridiculous prospect before half time. Stefan Savic attempted to head the ball back to his goalkeeper, but he misjudged and Viviano was forced into an acrobatic save to tip the ball over the bar. The resulting corner was then headed home by Daniele Portanova, making up for the way Ljajic ran rings round him for the Fiorentina goal.
Genoa seemed to be heartened by their goal, Cristobal Jorquera coming close with a dipping 25 yard strike that completely evaded Viviano.
Genoa's good work since the break was then seemingly undone by poor goalkeeping. Manuel Pasqual crossed from the left and Tzorvas had a seeminly routine catch that it looked like he'd made. The Greek then inexplicably dropped the ball, and Juan Cuadrado will never have an easier finish to put Fiorentina ahead again.
Five minutes later and the scores were level again. Juan Vargas's cross from the left was intelligently knocked down by Bosko Jankovic and Luca Antonelli was on hand to fire home on the volley leaving Vivano with no chance.
Genoa's chances took a distinct blow when Andrea Bertolacci was sent off for his second bookable offence on 76 minutes and it only took a minute for the advantage to tell, Mattia Cassani unfortunately deflecting a Fiorentina corner past his own goalkeeper.
With ten men, Genoa had a gargantuan task on their hand to get back on terms, and Fiorentina poured forward in search of a goal to seal it. Stefan Savic had a chance, ghosting unmarked into the box for a free kick but his diving header from six yards went wide. It didn't matter in the end, as Fiorentina held out to take the points for their Champions League charge.
Fiorentina: Viviano; Tomovic, Savic, Rodriguez, Pasqual; Aquilani (Fernandez 74), Valero (Miglaccio 88), Pizarro; Cuadrado, Ljajic Toni 74), Jovetic
Genoa: Tzorvas; Granqvist, Portanova, Moretti; Tozser (Jankovic 46), Pisano (Jorquera 46), Kucka, Vargas (Cassani 73), Antonelli; Bertolacci, Immobile
Goals: Aquilani 33 (F), Portanova 58 (G), Cuadrado 62 (F), Antonelli 69 (G), Cassani OG 77 (F)
Sent off: Bertolacci 76 (G)